4-Epioxytetracycline, 'can be used as secondary standard' (Thermo Scientific Chemicals™)

Key Features

General Description

• 4-Epioxytetracycline is a metabolite of the oxytetracycline compound that displays antibacterial activity
• It is the main degradation product derived from the oxytetracycline metabolization and has been detected in some biological samples
• Its mechanism of action has been described to be related to the mitochondrial protein synthesis inhibition

Applications

• In laboratory research it has been described that the treatment with 4-epioxytetracycline decreases the bacterial diversity of the intestinal microbiota and facilitates the proliferation of opportunistic pathogens in salmon
• The use of 4-epioxytetracycline in animal models (wistar rats) resulted in a significant alteration of the gut microbiota and disorders in blood metabolomics
• 4-Epioxytetracycline can be applied as a secondary reference standard during stability studies of oxytetracycline
• 4-epioxytetracycline has been used in research studies to evaluate the degradation pathway and products of tetracyclines

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