CaptureSelect™ LC-lambda (mouse) Affinity Matrix (Thermo Scientific™)

The CaptureSelect™ LC-lambda (mouse) Affinity Matrix contains a 13 kDa recombinant single domain antibody fragment (VHH affinity ligand) recognizing the lambda light chain of mouse Ig’s. The ligand is directed towards a unique domain on the constant part of the lambda light chain of immunoglobulins, which enables purification of mouse immunoglobulins and fab fragments without cross reactivity towards bovine immunoglobulins. This makes the CaptureSelect™ LC-lambda (mouse) Affinity Matrix a unique resin in terms of specificity. The ligand is coupled on a 70 μm aldehyde-activated agarose bead. This matrix can be used for the purification and isolation of lambda light chain-containing mouse immunoglobulins and fab fragments from complex sources like cell culture supernatants, plasma, and serum in a single step. Due to its non-reactivity to bovine Ig, FCS can be applied in growth media without disturbing purification.

Free of animal components
CaptureSelect products contain affinity ligands based on recombinant single-domain antibody fragments (VHH) created by a proprietary technology. The VHH affinity ligand is a 12 to 15 kDa fragment comprising the three complementarity-determining regions (CDRs) that form the antigen-binding domain, efficiently produced in the yeast Saccharomyces cerevisiae by a production process free of any animal components (Animal Origin-Free).