Silencer™ Human Ubiquitin siRNA Library (Invitrogen™)

Ubiquitination is a post-translational enzymatic modification that is essential to a wide array of cellular processes. These include immunological functions, apoptosis, biogenesis, DNA transcription and repair, cell cycle and division, cellular stress response, modulation of cell receptors and neural or muscular degeneration as well as disease and diagnostic-related processes. The Silencer™ Human Ubiquitin siRNA Library contains 2,898 Ambion™ Silencer siRNAs targeting 966 genes. The library was designed using the most up-to-date genome databases, including the NCBI RefSeq database and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC). Utilizing Ambion Silencer technology built on stringent bioinformatics to enable high target specificity and siRNA potency, the Silencer Human Ubiquitin siRNA Library is an ideal solution for focused and cost-effective RNAi screening against ubiquitin signaling.

• Comprehensive—Expedite your ubiquitin RNAi functional screens with pre-defined Silencer Human Ubiquitin siRNA Library
• Reliable—Increase target screening accuracy with three individual siRNAs per gene target
• Effective—Reduce off target impacts at low concentrations with proven Ambion Silencer siRNA design
• Convenient—Reduce data de-convolution and accelerate target validation with our arrayed format
• Customizable—Choose the best option for your workflow demands, including additional siRNA scales and pooled formats

Why use the Silencer Human Ubiquitin siRNA Library?
Together with careful bioinformatics selection of gene targets, Silencer siRNAs are optimized with design and high quality synthesis with guaranteed silencing (learn more about the guarantee). The Silencer Human Ubiquitin siRNA Library contains our pre-designed and when available, validated siRNAs generated with maximum potency and specificity in mind so you can focus on data quality (learn more about the design). All Silencer libraries are selected against the latest available databases and resources for up-to-date content. Full siRNA sequence information, as well as the exon targeted and each targeted gene's symbol, full name, aliases, RefSeq number, and Locus ID, plus results from any validation experiments performed using the included siRNAs is provided. Please contact us for the complete list of targets.

Silencer siRNA libraries allow you to screen efficiently and maximize data output
Ambion Silencer siRNAs are designed with potency in mind to help ensure gene knockdown at minimum concentrations. This not only helps ensure less potential for off target effects and false positive data but also minimizes false negative outcomes of siRNA screening. The Silencer Human Ubiquitin siRNA Library contains 0.25 nmol of each siRNA, sufficient for 100 transfections (at 25 nM siRNA, 100 μL transfection volume).

Flexibility to meet your workflow needs
Thermo Fisher Scientific offers a comprehensive list of pre-defined or custom siRNA libraries to human, mouse or rat genes with 1, 2, or 5 nmol of each siRNA or larger sizes. For a complete gene list, additional information or to discuss your research with one of our technical experts, contact your local sales representative or e-mail us at RNAilibraries@lifetech.